3D Antigen Design

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Our pipeline include antibodies addressing two receptors, progressing into pre clinical stage:

Immune Oncology

Clinical Indications:
Metastatic melanoma

Immune Oncology

Clinical Indications:
Metastatic melanoma, Metastatic lung cancer

Immune Oncology

Immune Oncology

Immune Oncology

Tikcro’s approach is based on 3D (three dimensional) antigens which are specifically designed to generate functional antibodies. This approach offer superior results in targeting discontinued epitopes. Tikcro aims to identify novel antibodies to validated immune targets and bring next-generation antibodies that increase the response rate of such treatments and decrease side effects by exclusively binding to the receptor or ligand of choice.

We have identified promising new antibody targets in the pathways of CTLA4 and PD1 receptors and their ligands, and are promoting such antibodies for further validation.

Tikcro, for the first time, successfully uses a novel technology of 3D designed antigens, which, post immunization of an animal, (rodent or the like), results with highly specific and functional antibodies.

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